- [Treatment of Overactive Bladder with Sodium Chondroitin Sulphate.] [article in German]
Gauruder-Burmester A, Wildt B, Tunn R. Zentralbl Gynakol 2006;128:336-40
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in this prospective randomized study it was tested whether instillation of sodium chondroitin sulphate for treatment of interstitial cystitis was also effective in treating overactive bladder
• 82 patients with chronic overactive bladder were randomized to one of two study groups A or B; group A was treated with an anticholinergic agent (tolterodine), group B with sodium chondroitin sulphate (Uropol S); patients were treated for 12 months
• the diagnosis was established on the basis of a gynecologic examination and history, urodynamic testing, introital ultrasound, and cystoscopy
• an improvement of symptoms was reported by 15/35 (43 %) of the patients in group A as compared with 23/32 (72 %) of the patients in group B; the subjective outcome was corroborated by means of urodynamic testing, number of pads used, voiding frequency, and nycturia (voiding diary); quality of life increased significantly in both groups in the course of treatment but there was no significant difference between both groups
• the authors conclude that restoring the glycosaminoglycan layer also improves or cures the symptoms in patients with overactive bladder
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